Hypermetabolism in mice carrying a near-complete human chromosome 21
The consequences of aneuploidy have traditionally been studied in cell and animal models in which the extrachromosomal DNA is from the same species.Here, we explore a fundamental question concerning the impact of aneuploidy Cinema Lens on systemic metabolism using a non-mosaic transchromosomic mouse model (TcMAC21) carrying a near-complete human ch